Journal article
role of acidity in solid tumour growth and invasion
- Abstract:
- Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the interaction between normal and tumour cell populations. Both vascular and avascular tumour dynamics are investigated, and a number of different behaviours are observed. Whilst an avascular tumour always proceeds to a benign steady state, a vascular tumour may display either benign or invasive
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Authors
- Journal:
- Journal of theoretical biology More from this journal
- Volume:
- 235
- Issue:
- 4
- Pages:
- 476-484
- Publication date:
- 2005-01-01
- UUID:
-
uuid:311e7863-5e92-45b9-b108-08010d4d8916
- Local pid:
-
cs:4322
- Deposit date:
-
2015-03-31
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- Copyright date:
- 2005
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