Journal article
Two-pore channels: going with the flows
- Abstract:
- In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasticity of cation conductances (Na+, Ca2+, H+) allow them to variously signal electrically, osmotically or chemically. Their relative tissue- and organelle-selective distribution, together with agonist-selective ion permeabilities provides a rich palette from which extracellular stimuli can choose. TPCs are emerging as mediators of immunity, cancer, metabolism, viral infectivity and neurodegeneration as this short review attests.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1042/bst20220229
Authors
- Publisher:
- Portland Press
- Journal:
- Biochemical Society Transactions More from this journal
- Volume:
- 50
- Issue:
- 4
- Pages:
- 1143-1155
- Place of publication:
- England
- Publication date:
- 2022-08-12
- Acceptance date:
- 2022-07-25
- DOI:
- EISSN:
-
1470-8752
- ISSN:
-
0300-5127
- Pmid:
-
35959977
- Language:
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English
- Keywords:
- Pubs id:
-
1274350
- Local pid:
-
pubs:1274350
- Deposit date:
-
2023-09-19
Terms of use
- Copyright holder:
- Morgan et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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