Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO)

Ng, DHL; Chia, TRT; Young, BE; Sadarangani, S; Puah, SH; Low, JGH; Yan, GZ; Mo, Y; Ngiam, NJ; Wang, SSY; Loo, YT; Ong, FEJQ; Li, AY; Ho, S; Ng, L; Tambyah, PA; Yeo, TW

Journal article

Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO)

Abstract:: Background: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region. Methods: RESPIRO is being conducted at three major tertiary hospitals in Singapore. Adults hospitalised with acute community-acquired pneumonia or lower respiratory tract infections, based on established clinical, laboratory and radiological criteria, will be recruited. Over the course of the illness, clinical data and biological samples will be collected longitudinally and stored in a biorepository for future analysis. Discussion: The RESPIRO study is designed to be hypothesis generating, complementary to and easily integrated with other research projects and clinical trials. The detailed clinical database and biorepository will yield insights into the epidemiology and outcomes of community-acquired lower respiratory tract infections in Singapore and the surrounding region and offers the opportunity to deeply characterise the microbiology and immunopathology of community-acquired pneumonia.National Medical Research Council (NMRC)Published versionThis study is funded by the National Medical Research Council (NMRC) Open Fund Large Collaborative Grant (Award ID: OFLCG19May-0034). It has no role in the conceptualization, design, data collection, analysis, or decision to publish and in preparation of the manuscript

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Ng, D. H. L., Chia, T. R. T., Young, B. E., Sadarangani, S., Puah, S. H., Low, J. G. H., Yan, G. Z., Mo, Y., Ngiam, N. J., Wang, S. S. Y., Loo, Y. T., Ong, F. E. J. Q., Li, A. Y., Ho, S., Ng, L., Tambyah, P. A., & Yeo, T. W. (2024). Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO). BMC Infectious Diseases, 24(1), 123–123.

MLA Style

Ng, DHL, et al. “Study Protocol: Infectious Diseases Consortium (I3D) for Study on Integrated and Innovative Approaches for Management of Respiratory Infections: Respiratory Infections Research and Outcome Study (RESPIRO).” BMC Infectious Diseases, vol. 24, no. 1, 2024, pp. 123–23.

Chicago Style

Ng, DHL, TRT Chia, BE Young, et al. 2024. “Study Protocol: Infectious Diseases Consortium (I3D) for Study on Integrated and Innovative Approaches for Management of Respiratory Infections: Respiratory Infections Research and Outcome Study (RESPIRO).” BMC Infectious Diseases 24 (1): 123–23.
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