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Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.

Abstract:

BACKGROUND: Several genome-wide association studies have recently linked a group of single nucleotide polymorphisms in the 9p21 region with cardiovascular disease. The molecular mechanisms of this link are not fully understood. We investigated five different expression microarray datasets in order to determine if the genotype had effect on expression of any gene transcript in aorta, mammary artery, carotid plaque and lymphoblastoid cells. METHODOLOGY/PRINCIPAL FINDINGS: After multiple testin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0007677

Authors


Folkersen, L More by this author
Kyriakou, T More by this author
Mälarstig, A More by this author
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Knut and Alice Wallenberg Foundation More from this funder
Danish Agency for Science, Technology and Innovation More from this funder
Fredrik Lundberg More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
11
Pages:
e7677
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:30c6de17-e857-4dd1-9d9f-78aecd9f028a
Source identifiers:
104380
Local pid:
pubs:104380

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