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The glutamate switch is present in all seven clades of AAA+ protein.

Abstract:
Recent work has identified a "glutamate switch" in six of the seven clades of AAA+ ATPases. The glutamate switch acts to transduce information regarding substrate binding to the ATPase active site. We provide biochemical evidence that a highly conserved threonine residue acts as a glutamate switch in the replicative helicase, MCM, and, thus, reveal that the glutamate switch is a feature common to all seven AAA+ clades.
Publication status:
Published

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Publisher copy:
10.1021/bi9012512

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Biochemistry
Volume:
48
Issue:
37
Pages:
8774-8775
Publication date:
2009-09-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:30bb53ee-8284-4744-b700-444ab94ce39d
Source identifiers:
489
Local pid:
pubs:489

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