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Journal article

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

Abstract:

Penicillin binding proteins (PBPs) catalyze steps in the biosynthesis of bacterial cell walls and are the targets for the beta-lactam antibiotics. Non-beta-lactam based antibiotics that target PBPs are of interest because bacteria have evolved resistance to the beta-lactam antibiotics. Boronic acids have been developed as inhibitors of the mechanistically related serine beta-lactamases and serine proteases; however, they have not been explored extensively as PBP inhibitors. Here we report aro...

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Publication status:
Published

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Publisher copy:
10.1021/jm9009718

Authors


Inglis, SR More by this author
Zervosen, A More by this author
Gerards, T More by this author
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Journal:
Journal of medicinal chemistry
Volume:
52
Issue:
19
Pages:
6097-6106
Publication date:
2009-10-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:30937105-a12f-4996-bc7b-4bd4696f0a9e
Source identifiers:
34875
Local pid:
pubs:34875

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