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Impact of IFNL4 genotype on interferon-stimulated gene expression during daa therapy for Hepatitis C

Abstract:

New directly acting antivirals (DAAs) provide very high cure rates in most patients infected by hepatitis C virus (HCV). However, some patient groups have been relatively harder to treat including those with cirrhosis or infected with HCV genotype 3. In the recent BOSON trial, genotype 3, cirrhotic patients receiving a 16 week course of sofosbuvir and ribavirin had a sustained virologic response rate (SVR) of around 50%. In cirrhotic patients, IFNL4 CC genotype was significantly associated wi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/hep.29877

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Wt Centre for Human Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Wt Centre for Human Genetics
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
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Publisher:
Wiley Publisher's website
Journal:
Hepatology Journal website
Volume:
68
Issue:
3
Pages:
859-871
Publication date:
2018-09-15
Acceptance date:
2018-03-08
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
Pubs id:
pubs:830418
URN:
uri:305d7b63-a78d-492e-9780-059f9c7b2b09
UUID:
uuid:305d7b63-a78d-492e-9780-059f9c7b2b09
Local pid:
pubs:830418

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