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Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience

Abstract:

Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic dysfunction and impairments in synaptic plasticity in the etiology of schizophrenia, including deficits associated with the GluA1 AMPAR subunit. GluA1 knockout (Gria1−/−) mice provide a model of impaired synaptic plasticity in schizophrenia and e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41380-022-01861-8

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Name:
Wellcome Trust
Grant:
202831/Z/16/Z
Publisher:
Springer Nature
Journal:
Molecular Psychiatry More from this journal
Volume:
28
Pages:
579-587
Publication date:
2022-12-02
Acceptance date:
2022-10-28
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Language:
English
Keywords:
Pubs id:
1285885
Local pid:
pubs:1285885
Deposit date:
2022-10-19

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