- Abstract:
-
The pharmacokinetic properties of oral artesunate (3 mg/kg) were determined in 10 Vietnamese children, aged from 6 to 15 years, with acute falciparum malaria of moderate severity. Plasma concentrations were measured using a bioassay and expressed in terms of antimalarial activity equivalent to dihydroartemisinin, the principal biologically active metabolite. Oral artesunate was absorbed rapidly with a mean time to peak plasma bioactivity of 1.7 h (95% confidence interval [95% CI] 0.8-2.6). Th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0035-9203(97)90222-4
-
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- Journal:
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Volume:
- 91
- Issue:
- 2
- Pages:
- 195-198
- Publication date:
- 1997-01-01
- DOI:
- EISSN:
-
1878-3503
- ISSN:
-
0035-9203
- URN:
-
uuid:30361f72-9acd-4203-8928-717c6af4f947
- Source identifiers:
-
45507
- Local pid:
- pubs:45507
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria.
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