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Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria.

Abstract:

The pharmacokinetic properties of oral artesunate (3 mg/kg) were determined in 10 Vietnamese children, aged from 6 to 15 years, with acute falciparum malaria of moderate severity. Plasma concentrations were measured using a bioassay and expressed in terms of antimalarial activity equivalent to dihydroartemisinin, the principal biologically active metabolite. Oral artesunate was absorbed rapidly with a mean time to peak plasma bioactivity of 1.7 h (95% confidence interval [95% CI] 0.8-2.6). Th...

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Publication status:
Published

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
91
Issue:
2
Pages:
195-198
Publication date:
1997-01-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:30361f72-9acd-4203-8928-717c6af4f947
Source identifiers:
45507
Local pid:
pubs:45507

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