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Journal article

BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer.

Abstract:

Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes. Through genomic analysis of colorectal cancers and cell lines, we find frequent loss of heterozygosity and mutations in BCL9L in aneuploid tumors. BCL9L deficiency promoted tolerance of chromosome missegregation events, propagation of aneuploidy, and genetic hete...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ccell.2016.11.001

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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NovoNordisk Foundation More from this funder
Breast Cancer Research Foundation More from this funder
Prostate Cancer Foundation More from this funder
Stand Up 2 Cancer More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cancer Cell Journal website
Volume:
31
Issue:
1
Pages:
79-93
Publication date:
2017-01-01
Acceptance date:
2016-10-28
DOI:
EISSN:
1878-3686
ISSN:
1535-6108

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