Journal article icon

Journal article

BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer.

Abstract:

Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes. Through genomic analysis of colorectal cancers and cell lines, we find frequent loss of heterozygosity and mutations in BCL9L in aneuploid tumors. BCL9L deficiency promoted tolerance of chromosome missegregation events, propagation of aneuploidy, and genetic hete...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.ccell.2016.11.001

Authors


More by this author
Department:
Oxford, MSD, Oncology
Role:
Author
Expand authors...
Stand Up 2 Cancer More from this funder
Rosetrees Trust More from this funder
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
Cancer Cell Journal website
Volume:
31
Issue:
1
Pages:
79-93
Publication date:
2017-01-05
Acceptance date:
2016-10-28
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
Pubs id:
pubs:671498
URN:
uri:303602f2-2712-4b1a-8449-577d3cb2a45a
UUID:
uuid:303602f2-2712-4b1a-8449-577d3cb2a45a
Local pid:
pubs:671498

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP