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Unraveling the composition and behavior of heterogeneous lipid nanodiscs by mass spectrometry

Abstract:

Mass spectrometry (MS) has emerged as a powerful tool to study membrane protein complexes and protein-lipid interactions. Because they provide a precisely-defined lipid bilayer environment, lipoprotein Nanodiscs offer a promising cassette for membrane protein MS analysis. However, heterogeneous lipids create several potential challenges for native MS: additional spectral complexity, ambiguous assignments, and differing gas-phase behaviors. Here, we present strategies to address these challeng...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1021/acs.analchem.6b00851

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
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Funding agency for:
Robinson, CV
Publisher:
American Chemical Society Publisher's website
Journal:
Analytical Chemistry Journal website
Volume:
88
Issue:
12
Pages:
6199–6204
Publication date:
2016-05-05
Acceptance date:
2016-05-20
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
URN:
uuid:3033527a-303c-43d1-bc8b-a99fa6609f23
Source identifiers:
624906
Local pid:
pubs:624906

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