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Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo.

Abstract:

The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear. To investigate this, we injected tuberculin purified protein derivative (PPD) into the skin of immune individuals and isolated responsive T cells from the site of antigenic challenge at different times. PPD-specific CD4+ T cells proliferated and differentiated extensively in the skin during this secondary response. Furthermore, signi...

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Publisher copy:
10.1084/jem.20040178

Authors


Vukmanovic-Stejic, M More by this author
Fletcher, JM More by this author
Soares, MV More by this author
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Journal:
The Journal of experimental medicine
Volume:
199
Issue:
10
Pages:
1433-1443
Publication date:
2004-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3023f882-5d77-4fd4-8315-32656e454d87
Source identifiers:
32711
Local pid:
pubs:32711

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