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The effects of selection on linkage analysis for quantitative traits.

Abstract:

The effects of within-sample selection on the outcome of analyses detecting linkage between genetic markers and quantitative traits were studied. It was found that selection by truncation for the trait of interest significantly reduces the differences between marker genotype means thus reducing the power to detect linked quantitative trait loci (QTL). The size of this reduction is a function of proportion selected, the magnitude of the QTL effect, recombination rate between the marker locus a...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Genetics
Volume:
132
Issue:
4
Pages:
1177-1185
Publication date:
1992-12-01
EISSN:
1943-2631
ISSN:
0016-6731
Source identifiers:
90481
Language:
English
Keywords:
Pubs id:
pubs:90481
UUID:
uuid:2fe96cbf-93e1-497e-be33-995c0427d69b
Local pid:
pubs:90481
Deposit date:
2012-12-19

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