Extracellular signal-regulated kinases 1/2 and their role in cardiac diseases

Journal article

Mitogen-activated protein (MAP) kinases comprise a well-studied family of serine/threonine protein kinases involved in signal transduction pathways that control multiple cellular processes. The extracellular signal-regulated kinase (ERK1/2) cascade is a central MAP kinase pathway that transmits signals from the cell surface to substrates either in the nucleus or in the cytoplasm. The transmission of the signal through the ERK1/2 cascade is mediated by phosphorylation and activation of protein kinases. Abnormal regulation of the ERK1/2 signals has been linked to diseases and recent work clearly implicated ERK1/2 signaling in the development of cardiac pathologies. Understanding the underlying mechanism and the consequences of the aberrant modulation of ERK1/2 cascade will lead to the development of pharmacologic inhibitors for the treatment of these cardiac disorders.

Authors: Chatzifrangkeskou, M; Muchir, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Smart Science and Technology
• Journal: Science Proceedings
• Volume: 02
• Pages: 1-4
• Publication date: 2015-01-28
• DOI: 10.14800/sp.457
• ISSN: 2375-7795
• Keywords: SBTMR