A platform trial design for preventive vaccines against Marburg virus and other emerging infectious disease threats
Background The threat of a possible Marburg virus disease outbreak in Central and Western Africa is growing. While no Marburg virus vaccines are currently available for use, several candidates are in the pipeline. Building on knowledge and experiences in the designs of vaccine efficacy trials against other pathogens including SARS-CoV-2, we develop designs of randomized phase 3 vaccine efficacy trials for Marburg virus vaccines.
Methods: A core protocol ... Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
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