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Tetrameric complexes of HLA-E, HLA-F, and HLA-G.

Abstract:

HLA-E, HLA-F, and HLA-G are human nonclassical MHC class Ib molecules. To study the function and identify potential ligands of these molecules, we constructed tetrameric complexes. In this brief review, we discuss the methods used to produce such tetramers and the interesting results they provided. HLA-E tetramers bound to natural killer (NK) cells and T cells, allowing the identification of CD94/NKG2 molecules as receptors for HLA-E. HLA-G tetramers interacted with immunoglobulin-like transc...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Journal of immunological methods
Volume:
268
Issue:
1
Pages:
43-50
Publication date:
2002-10-05
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
URN:
uuid:2f9e6d3a-50db-4670-ab70-27814ff3caf6
Source identifiers:
21597
Local pid:
pubs:21597

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