Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Journal article

The Alphainfluenzavirus influenzae (FLUAV), is an enveloped, negative sense, single stranded RNA virus and part of the Orthomyxoviridae family. The FLUAV is comprised of eight genome segments, with segments HA and NA being the primary targets for host humoral responses and determining the subtypes of the influenza viruses. N-linked glycosylation may occur at the N-X-S/T sequon sites of NA and HA, and potentially impact the structure of HA and NA and thus transmissibility, antigenicity, and/or immunology of the FLUAV. FLUAVs circulating in humans have shown an increase of N-linked glycosylation sites, compared to those circulating in avian. Monitoring the heterogenicity and site occupancy of N-linked glycosylation is important in understanding the national history of FLUAVs. Advancements in glycomics technology and methods have helped precisely characterize N-linked glycosylation and develop therapeutic targets and broadly protective vaccines for influenza prevention and control.Includes bibliographical references

Authors: Guthmiller, JJ; Han, J; Utset, HA; Li, L; Lan, LY-L

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature
• Volume: 602
• Issue: 7896
• Pages: 314-320
• Publication date: 2021-12-23
• DOI: 10.1038/s41586-021-04356-8
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Influenza A virus; Virology; Neutralizing antibody; Antibody Repertoire; Biology; Virus; Antigenic drift; Epitope; Antibody; Immunology