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Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.

Abstract:

Phenytoin and carbamazepine are effective and inexpensive anti-epileptic drugs (AEDs). As with many AEDs, a broad range of doses is used, with the final "maintenance" dose normally determined by trial and error. Although many genes could influence response to these medicines, there are obvious candidates. Both drugs target the alpha-subunit of the sodium channel, encoded by the SCN family of genes. Phenytoin is principally metabolized by CYP2C9, and both are probable substrates of the drug tr...

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Publisher copy:
10.1073/pnas.0407346102

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
15
Pages:
5507-5512
Publication date:
2005-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:2f73a1bf-267f-4385-bc6b-11532beea362
Source identifiers:
461831
Local pid:
pubs:461831

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