- Abstract:
-
Phenytoin and carbamazepine are effective and inexpensive anti-epileptic drugs (AEDs). As with many AEDs, a broad range of doses is used, with the final "maintenance" dose normally determined by trial and error. Although many genes could influence response to these medicines, there are obvious candidates. Both drugs target the alpha-subunit of the sodium channel, encoded by the SCN family of genes. Phenytoin is principally metabolized by CYP2C9, and both are probable substrates of the drug tr...
Expand abstract - Publisher copy:
- 10.1073/pnas.0407346102
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 102
- Issue:
- 15
- Pages:
- 5507-5512
- Publication date:
- 2005-04-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:2f73a1bf-267f-4385-bc6b-11532beea362
- Source identifiers:
-
461831
- Local pid:
- pubs:461831
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.
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