Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes.

Journal article

Molecular imaging of tumour tissue focusses mainly on extracellular epitopes such as tumour angiogenesis or signal transduction receptors expressed on the cell membrane. However, most biological processes that define tumour phenotype occur within the cell. In this mini-review, an overview is given of the various techniques to interrogate intracellular events using molecular imaging with radiolabelled compounds. Additionally, similar targeting techniques can be employed for radionuclide therapy using Auger electron emitters, and recent advances in Auger electron therapy are discussed.

Authors: Cornelissen, B

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: John Wiley & Sons, Ltd
• Journal: Journal of labelled compounds and radiopharmaceuticals
• Volume: 57
• Issue: 4
• Pages: 310-316
• Publication date: 2014-04-01
• DOI: 10.1002/jlcr.3152
• EISSN: 1099-1344
• ISSN: 0362-4803
• Language: English
• Keywords: molecular imaging; molecular targeted therapy; radionuclide imaging; intracellular space; cell penetrating peptide; nuclear localisation sequence; epitopes; cell nucleus; PET; Auger electron; SPECT; neoplasms