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Journal article

A pancreatic islet-specific microRNA regulates insulin secretion.

Abstract:

MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression. Several miRNAs in animals exhibit tissue-specific or developmental-stage-specific expression, indicating that they could play important roles in many biological processes. To study the role of miRNAs in pancreatic endocrine cells we cloned and identified a novel, evolutionarily conserved and islet-specific miRNA (miR-375). Here we show that overexpression ...

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Publication status:
Published

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Publisher copy:
10.1038/nature03076

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Journal:
Nature
Volume:
432
Issue:
7014
Pages:
226-230
Publication date:
2004-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:2f70a233-9e5f-4f98-b0f8-dc6037a26ba4
Source identifiers:
29630
Local pid:
pubs:29630

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