Journal article
Catalysed amplification of faradaic shotgun tagging in ultrasensitive electrochemical immunoassays
- Abstract:
- We introduce a novel electrochemical protein quantitation based on the shotgun biotin tagging of proteins prior to their interfacial immunocapture and polymeric enzyme tagging. The highly amplified faradaic signals generated from a novel ferrocene-tyramine adduct enable fg mL-1 (attomolar) levels of detection and span cross a 5 orders of magnitude dynamic range. This work supports ultrasensitive protein marker detection in a single antibody immunoassay format.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 985.7KB, Terms of use)
-
- Publisher copy:
- 10.1039/d2cc03509j
Authors
- Publisher:
- Royal Society of Chemistry
- Journal:
- Chemical Communications More from this journal
- Volume:
- 58
- Issue:
- 68
- Pages:
- 9472-9475
- Publication date:
- 2022-08-23
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- Language:
-
English
- Keywords:
- Pubs id:
-
1275246
- Local pid:
-
pubs:1275246
- Source identifiers:
-
W4290754975
- Deposit date:
-
2026-04-28
- ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.
Terms of use
- Copyright date:
- 2022
If you are the owner of this record, you can report an update to it here: Report update to this record