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The alarmin IL-33 is a notch target in quiescent endothelial cells.

Abstract:

The molecular mechanisms that drive expression of the alarmin interleukin-33 (IL-33) in endothelial cells are unknown. Because nuclear IL-33 is a marker of endothelial cell quiescence (corroborated in this study by coexpression of cyclin-dependent kinase inhibitor p27(Kip1)), we hypothesized that Notch signaling might be involved in regulating IL-33 expression. Activation of Notch1 by immobilized Notch ligands was sufficient to induce nuclear IL-33 expression in cultured endothelial cells. Co...

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Publication status:
Published

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Authors


Sundlisaeter, E More by this author
Edelmann, RJ More by this author
Sponheim, J More by this author
Küchler, AM More by this author
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Journal:
The American journal of pathology
Volume:
181
Issue:
3
Pages:
1099-1111
Publication date:
2012-09-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:2f3720d4-2e42-42ab-a05c-bc22a374d3ec
Source identifiers:
342392
Local pid:
pubs:342392

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