Journal article
Predicting the prevalence of chronic kidney disease in the English population: a cross-sectional study
- Abstract:
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Background: There is concern that not all cases of chronic kidney disease (CKD) are known to general practitioners, leading to an underestimate of its true prevalence. We carried out this study to develop a model to predict the prevalence of CKD using a large English primary care dataset which includes previously undiagnosed cases of CKD.
Methods: Cross-sectional analysis of data from the Quality Improvement in CKD trial, a representative sample of 743 935 adults in England aged 18 and over. We created multivariable logistic regression models to identify important predictive factors.
Results: A prevalence of 6.76% was recorded in our sample, compared to a national prevalence of 4.3%. Increasing age, female gender and cardiovascular disease were associated with a significantly increased prevalence of CKD (p < 0.001 for all). Age had a complex association with CKD. Cardiovascular disease was a stronger predictive factor in younger than in older patients. For example, hypertension has an odds ratio of 2.02 amongst patients above average and an odds ratio of 3.91 amongst patients below average age.
Conclusion: In England many cases of CKD remain undiagnosed. It is possible to use the results of this study to identify areas with high levels of undiagnosed CKD and groups at particular risk of having CKD.
Trial registration: Current Controlled Trials ISRCTN: ISRCTN56023731. Note that this study reports the results of a cross-sectional analysis of data from this trial.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 515.8KB, Terms of use)
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- Publisher copy:
- 10.1186/1471-2369-14-49
Authors
- Publisher:
- BioMed Central
- Journal:
- BMC Nephrology More from this journal
- Volume:
- 14
- Issue:
- 1
- Article number:
- 49
- Publication date:
- 2013-02-25
- Acceptance date:
- 2013-02-13
- DOI:
- EISSN:
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1471-2369
- Pmid:
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23442335
- Language:
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English
- Keywords:
- Pubs id:
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1013859
- Local pid:
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pubs:1013859
- Deposit date:
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2024-06-06
Terms of use
- Copyright holder:
- Kearns et al.
- Copyright date:
- 2013
- Rights statement:
- Copyright © 2013, Kearns et al; licensee BioMed Central Ltd. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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