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The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.

Abstract:

Many tumors contain extensive regions of hypoxia. Because hypoxic cells are markedly more resistant to killing by radiation, repeated attempts have been made to improve the oxygenation of tumors to enhance radiotherapy. We have studied the oxygenation of tumor xenografts in nude mice after treatment with the farnesyltransferase inhibitor L744,832. Hypoxia was assessed by measuring the binding of the hypoxic cell marker pentafluorinated 2-nitroimidazole. We show that xenografts from two tumor ...

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Publication status:
Published

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Authors


Cohen-Jonathan, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Cancer research
Volume:
61
Issue:
5
Pages:
2289-2293
Publication date:
2001-03-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:2f0b9155-360d-4fec-8a07-d1f9bb8315c7
Source identifiers:
118177
Local pid:
pubs:118177

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