Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

Journal article

This study provides evidence for a broad impact of adiposity on the human proteome. Proteins strongly altered by BMI include those involved in regulating appetite, sex hormones and inflammation; such proteins are also enriched for cardiovascular disease-related genes. Altogether, results help focus attention onto new proteomic signatures of obesity-related disease.

Authors: Goudswaard, LJ; Bell, JA; Hughes, DA; Corbin, LJ; Walter, K

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature [academic journals on nature.com]
• Journal: International Journal of Obesity
• Volume: 45
• Issue: 10
• Pages: 2221-2229
• Publication date: 2021-07-05
• DOI: 10.1038/s41366-021-00896-1
• EISSN: 1476-5497
• ISSN: 0307-0565
• Language: English
• Keywords: Observational study; Leptin; Sex hormone-binding globulin; Hormone; Genome-wide association study; Medicine; Confounding; Single-nucleotide polymorphism; Biology; Genetics; Endocrinology; Mendelian randomization; Obesity; Internal medicine; Gene; Body mass index; Genotype