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Journal article

Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins.

Abstract:

Clinical experience with adenovirus vectors has highlighted the need for improved delivery and targeting. Tumour-associated endothelium offers an additional mechanism for enhanced viral uptake into tumours which is accessible for systemic gene delivery. Building on expertise in using polymer 'stealthed' viruses for targeting in vivo, adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] to ablate normal infection ...

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Publication status:
Published

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Authors


Bachtarzi, H More by this author
Stevenson, M More by this author
Ulbrich, K More by this author
Seymour, LW More by this author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
150
Issue:
2
Pages:
196-203
Publication date:
2011-03-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:2efd5d8f-17fa-4176-92dc-6c72f502ae10
Source identifiers:
179189
Local pid:
pubs:179189

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