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Prophylactic acetaminophen or ibuprofen result in equivalent acute mountain sickness incidence at high altitude: a prospective randomized trial

Abstract:
Objective Recent trials have demonstrated the usefulness of ibuprofen in the prevention of acute mountain sickness (AMS), yet the proposed anti-inflammatory mechanism remains unconfirmed. Acetaminophen and ibuprofen were tested for AMS prevention. We hypothesized that a greater clinical effect would be seen from ibuprofen due to its anti-inflammatory effects compared with acetaminophen’s mechanism of possible symptom reduction by predominantly mediating nociception in the bra... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.wem.2016.12.011

Authors


Kanaan, NC More by this author
Peterson, AL More by this author
Starling, J More by this author
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Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Wilderness and Environmental Medicine Journal website
Volume:
28
Issue:
2
Pages:
72-78
Publication date:
2017-05-04
Acceptance date:
2016-12-30
DOI:
ISSN:
1080-6032
Pubs id:
pubs:695938
URN:
uri:2ee21c6a-5057-4443-a80a-a2bbf4a6fd42
UUID:
uuid:2ee21c6a-5057-4443-a80a-a2bbf4a6fd42
Local pid:
pubs:695938

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