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Template-directed conjugation of heterogeneous oligonucleotides to a homobifunctional molecule for programmable supramolecular assembly

Abstract:

Nanoscience aspires to mimic nature's control over functional molecular assemblies. Here we present a templating technique for the efficient attachment of two different oligonucleotides to a homobifunctional molecule, enabling its controlled and programmable placement within a DNA nanostructure. We demonstrate its application to a range of organic molecules with different conjugation chemistries and water solubilities. We show that the two oligonucleotide adapters can be used to integrate a b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/D2NR00197G

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
Magdalen College
Role:
Author
ORCID:
0000-0002-3876-0190
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/P000479/1
Publisher:
Royal Society of Chemistry
Journal:
Nanoscale More from this journal
Volume:
14
Issue:
12
Pages:
4463-4468
Publication date:
2022-02-28
Acceptance date:
2022-02-28
DOI:
EISSN:
2040-3372
ISSN:
2040-3364
Language:
English
Keywords:
Pubs id:
1241711
Local pid:
pubs:1241711
Deposit date:
2022-02-28

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