Journal article icon

Journal article

The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.

Abstract:

The Moonwalker (Mwk) mouse is a model of dominantly inherited cerebellar ataxia caused by a gain-of-function mutation in the transient receptor potential (TRP) channel TRPC3. Here, we report impairments in dendritic growth and synapse formation early on during Purkinje cell development in the Mwk cerebellum that are accompanied by alterations in calcium signaling. To elucidate the molecular effector pathways that regulate Purkinje cell dendritic arborization downstream of mutant TRPC3, we emp...

Expand abstract
Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publishers version

Actions


Access Document


Files:
Publisher copy:
10.1093/hmg/ddv150

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Kessler, BM
More from this funder
Funding agency for:
Becker, EB
Medical Research Council More from this funder
Royal Society More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
24
Issue:
14
Pages:
4114-4125
Publication date:
2015-04-23
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:2e89aaa6-25c4-4b5d-8d13-070282f5d2e8
Source identifiers:
519200
Local pid:
pubs:519200
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP