Obesity and statins are both independent predictors of enhanced coronary arteriolar dilation in patients undergoing heart surgery.
BACKGROUND: A paradoxical inverse relationship between body mass index, morbidity and mortality in patients with ischemic heart disease has been noted; but the underlying mechanisms remain unclear. Given that coronary resistance arteries are the primary regulators of myocardial blood flow, we examined the effects of obesity and medication on dilator function in coronary microvessels. METHODS: Bradykinin-induced coronary dilation was assessed by videomicroscopy in ex vivo coronary arterioles o...Expand abstract
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