Journal article
Dietary fiber intake and risk of advanced and aggressive forms of prostate cancer: a pooled analysis of 15 prospective cohort studies
- Abstract:
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Background
Evidence of an association between dietary fiber intake and risk of advanced and aggressive forms of prostate cancer (PC) and PC mortality is limited.Objective
The aim of this study was to examine associations between intakes of dietary fiber overall and by food source and risk of advanced and aggressive forms of PC.Design
The study design was a pooled analysis of the primary data from 15 cohorts in 3 continents. Baseline dietary fiber intake was assessed using a validated food frequency questionnaire or diet history in each study.Participants/setting
There were 842 149 men followed for up to 9 to 22 years between 1985 and 2009 across studies.Main outcome measures
The primary outcome measures were advanced (stage T4, N1, or M1 or PC mortality), advanced restricted (excluded men with missing stage and those with localized PC who died of PC), and high-grade PC (Gleason score ≥8 or poorly differentiated/undifferentiated) and PC mortality.Statistical analysis performed
Study-specific multivariable hazard ratios (MVHR) were calculated using Cox proportional hazards regression and pooled using random effects models.Results
Intake of dietary fiber overall, from fruits, and from vegetables was not associated with risk of advanced (n = 4863), advanced restricted (n = 2978), or high-grade PC (n = 9673) or PC mortality (n = 3097). Dietary fiber intake from grains was inversely associated with advanced PC (comparing the highest vs lowest quintile, MVHR 0.84; 95% CI 0.76-0.93), advanced restricted PC (MVHR 0.85; 95% CI 0.74-0.97), and PC mortality (MVHR 0.78; 95% CI 0.68-0.89); statistically significant trends were noted for each of these associations (P ≤ .03), and a null association was observed for high-grade PC for the same comparison (MVHR 1.00; 95% CI 0.93-1.07). The comparable results were 1.06 (95% CI 1.01-1.10; P value, test for trend = .002) for localized PC (n = 35,199) and 1.05 (95% CI 0.99-1.11; P value, test for trend = .04) for low/intermediate grade PC (n = 34 366).Conclusions
Weak nonsignificant associations were observed between total dietary fiber intake and risk of advanced forms of PC, high-grade PC, and PC mortality. High dietary fiber intake from grains was associated with a modestly lower risk of advanced forms of PC and PC mortality.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 2.9MB, Terms of use)
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- Publisher copy:
- 10.1016/j.jand.2024.04.006
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of the Academy of Nutrition and Dietetics More from this journal
- Volume:
- 125
- Issue:
- 1
- Pages:
- 11-23.e22
- Place of publication:
- United States
- Publication date:
- 2024-04-15
- Acceptance date:
- 2024-04-08
- DOI:
- EISSN:
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2212-2680
- ISSN:
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2212-2672
- Pmid:
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38636793
- Language:
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English
- Keywords:
- Pubs id:
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1991328
- Local pid:
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pubs:1991328
- Deposit date:
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2024-07-26
- ARK identifier:
Terms of use
- Copyright holder:
- Sidahmed et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 Published by Elsevier Inc on behalf of the Academy of Nutrition and Dietetics.
- Notes:
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For the purpose of open access, the authors have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.
This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://dx.doi.org/10.1016/j.jand.2024.04.006
- Licence:
- CC Attribution (CC BY)
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