Journal article
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
- Abstract:
-
The endothelins are a family of endothelium-derived peptides that possess a variety of biological activities, including potent vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and pulmonary fibrosis. Here, we use genome-wide expression array analysis to show that the addition of ET-1 (100 nm, 4 h) to normal lung fibroblasts directly induces expression of matrix and matrix-associated genes, including the profibrotic protein CCN2 (connective tissue growth factor, or CT...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m400516200
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 279
- Issue:
- 22
- Pages:
- 23098-23103
- Publication date:
- 2004-05-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
223490
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:223490
- UUID:
-
uuid:2e338bb4-0180-412e-88f3-09dea7cd7aaf
- Local pid:
- pubs:223490
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2004
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