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Journal article

Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.

Abstract:

The endothelins are a family of endothelium-derived peptides that possess a variety of biological activities, including potent vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and pulmonary fibrosis. Here, we use genome-wide expression array analysis to show that the addition of ET-1 (100 nm, 4 h) to normal lung fibroblasts directly induces expression of matrix and matrix-associated genes, including the profibrotic protein CCN2 (connective tissue growth factor, or CT...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m400516200

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Journal:
The Journal of biological chemistry
Volume:
279
Issue:
22
Pages:
23098-23103
Publication date:
2004-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:2e338bb4-0180-412e-88f3-09dea7cd7aaf
Source identifiers:
223490
Local pid:
pubs:223490

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