Journal article
A modular, enantioselective synthesis of resolvins D3, E1, and hybrids
- Abstract:
- Resolvins D3 and E1 are important signaling molecules in the resolution of inflammation. Here, we report a convergent and flexible strategy to prepare these natural products using Hiyama-Denmark coupling of five- and six-membered cyclic alkenylsiloxanes to connect three resolvin fragments, and control the stereochemistry of the natural product (Z)-alkenes. The modular nature of this approach enables the synthesis of novel resolvin hybrids, opening up opportunities for more-extensive investigations of resolvin biology.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.orglett.0c00089
Authors
- Publisher:
- American Chemical Society
- Journal:
- Organic letters More from this journal
- Volume:
- 22
- Issue:
- 4
- Pages:
- 1510-1515
- Publication date:
- 2020-02-07
- DOI:
- EISSN:
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1523-7052
- ISSN:
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1523-7060
- Pmid:
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32031820
- Language:
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English
- Pubs id:
-
1086003
- Local pid:
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pubs:1086003
- Deposit date:
-
2020-03-02
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2020
- Rights statement:
- © 2020 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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