- Abstract:
-
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5+ stem cells. Simultaneous deletion of the two genes encoding these proteins in the intestinal epithelium of mice induces rapidly growing adenomas containing high numbers of Paneth and LGR5+ stem cells. In vitro, growth of organoids derived from these ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nature11308
-
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- Journal:
- Nature
- Volume:
- 488
- Issue:
- 7413
- Pages:
- 665-669
- Publication date:
- 2012-08-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:2e12aea4-5c33-4d9d-8ab1-cb65c2a31a39
- Source identifiers:
-
384550
- Local pid:
- pubs:384550
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
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