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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Abstract:

LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5+ stem cells. Simultaneous deletion of the two genes encoding these proteins in the intestinal epithelium of mice induces rapidly growing adenomas containing high numbers of Paneth and LGR5+ stem cells. In vitro, growth of organoids derived from these ...

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Publication status:
Published

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Publisher copy:
10.1038/nature11308

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Journal:
Nature
Volume:
488
Issue:
7413
Pages:
665-669
Publication date:
2012-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:2e12aea4-5c33-4d9d-8ab1-cb65c2a31a39
Source identifiers:
384550
Local pid:
pubs:384550

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