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Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Abstract:

Objective

Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key aminopeptidase in HLA class I presentation and can potentially alter surface expression of HLA-B27 free heavy chains (FHCs). We studied the effects of ERAP1 silencing/inhibition/variations on HLAB27 FHC expression and Th17 responses in AS.

Methods

Flow cytometry was used to measure surface expressio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/annrheumdis-2014-206996

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Department:
Oxford, MSD, NDORMS
Role:
Author
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Department:
Oxford, MSD, NDORMS
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Funding agency for:
Al-Mossawi, MH
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Volume:
75
Pages:
916-923
Publication date:
2015-06-05
Acceptance date:
2015-04-12
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:2e07f9cd-e5f6-448e-8b1d-eba856e34774
Source identifiers:
529378
Local pid:
pubs:529378
Language:
English
Keywords:

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