- Abstract:
-
Objective
Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key aminopeptidase in HLA class I presentation and can potentially alter surface expression of HLA-B27 free heavy chains (FHCs). We studied the effects of ERAP1 silencing/inhibition/variations on HLAB27 FHC expression and Th17 responses in AS.
Methods
Flow cytometry was used to measure surface expressio...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 5.7MB)
-
- Publisher copy:
- 10.1136/annrheumdis-2014-206996
-
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- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Annals of the Rheumatic Diseases Journal website
- Volume:
- 75
- Pages:
- 916-923
- Publication date:
- 2015-06-05
- Acceptance date:
- 2015-04-12
- DOI:
- EISSN:
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1468-2060
- ISSN:
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0003-4967
- URN:
-
uuid:2e07f9cd-e5f6-448e-8b1d-eba856e34774
- Source identifiers:
-
529378
- Local pid:
- pubs:529378
- Language:
- English
- Keywords:
- Copyright holder:
- Bowness et al
- Copyright date:
- 2015
- Notes:
- This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
Journal article
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.
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