Journal article
Mechanism of protein kinetic stabilization by engineered disulfide crosslinks
- Abstract:
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The impact of disulfide bonds on protein stability goes beyond simple equilibrium thermodynamics effects associated with the conformational entropy of the unfolded state. Indeed, disulfide crosslinks may play a role in the prevention of dysfunctional association and strongly affect the rates of irreversible enzyme inactivation, highly relevant in biotechnological applications. While these kinetic-stability effects remain poorly understood, by analogy with proposed mechanisms for processes of ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0070013
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 8
- Issue:
- 7
- Pages:
- e70013
- Publication date:
- 2013-07-30
- Acceptance date:
- 2013-06-14
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:659849
- UUID:
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uuid:2e046fe4-870a-49d6-aed9-94c15fc726ca
- Local pid:
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pubs:659849
- Source identifiers:
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659849
- Deposit date:
-
2016-12-13
Terms of use
- Copyright holder:
- Sanchez-Romero et al
- Copyright date:
- 2013
- Notes:
-
©2013 Sanchez-Romero et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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