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The structure of serum resistance-associated protein and its implications for human African trypanosomiasis

Abstract:

Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2. These lipoprotein complexes contain an active, pore-forming component, apolipoprotein L1 (ApoL1), that causes trypanosome cell death. One of the two human-infective subspecies, Trypanosoma brucei rhodesiense, differs from non-infective ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41564-017-0085-3

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
3
Pages:
295-301
Publication date:
2018-01-22
Acceptance date:
2017-11-27
DOI:
EISSN:
2058-5276
Pubs id:
pubs:821278
URN:
uri:2df7ab90-1194-4c34-a4ea-54033f855b60
UUID:
uuid:2df7ab90-1194-4c34-a4ea-54033f855b60
Local pid:
pubs:821278
Language:
English
Keywords:

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