Journal article
Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
- Abstract:
-
Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to protection from severe malaria. Early reports suggested most G6PD deficiency in sub-Saharan Africa was because of the 202A/376G G6PD A-allele, and recent association studies of G6PD deficiency have employed genotyping as a convenient way to determine enzyme status. However, further work has suggested that other G6PD deficiency alleles are relatively common in some regions of West Africa. To investigate the c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/ejhg.2009.8
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Authors
Funding
Bill and Melinda Gates Foundation
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Wellcome Trust
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Medical Research Council
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Bibliographic Details
- Publisher:
- Macmillan Publishers Ltd. Publisher's website
- Journal:
- European Journal of Human Genetics Journal website
- Volume:
- 17
- Issue:
- 8
- Pages:
- 1080-1085
- Publication date:
- 2009-08-01
- DOI:
- EISSN:
-
1476-5438
- ISSN:
-
1018-4813
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2deef271-4eee-4d89-9420-0d726f03573b
- Local pid:
- ora:4333
- Deposit date:
- 2010-10-29
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Terms of use
- Copyright holder:
- Macmillan Publisher Limited
- Copyright date:
- 2009
- Notes:
- The full-text of this article is not currently available in ORA, but you may be able to access the article via the publisher copy link on this record page. Citation: Clark, T. G. et al. (2009). 'Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility', European Journal of Human Genetics 17(8), 1080-1085. [Available at http://www.nature.com/ejhg/journal/v17/n8/full/ejhg20098a.html].
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