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Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility

Abstract:

Several lines of evidence link glucose-6-phosphate dehydrogenase (G6PD) deficiency to protection from severe malaria. Early reports suggested most G6PD deficiency in sub-Saharan Africa was because of the 202A/376G G6PD A-allele, and recent association studies of G6PD deficiency have employed genotyping as a convenient way to determine enzyme status. However, further work has suggested that other G6PD deficiency alleles are relatively common in some regions of West Africa. To investigate the c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ejhg.2009.8

Authors


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Institution:
Wellcome Trust Sanger Institute, Hinxton, Cambridge
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
More by this author
Institution:
Wellcome Trust Sanger Institute, Hinxton, Cambridge
More by this author
Institution:
Wellcome Trust Sanger Institute, Hinxton, Cambridge
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Funding agency for:
Andrew E. Fry
Bill and Melinda Gates Foundation More from this funder
Wellcome Trust More from this funder
Medical Research Council More from this funder
Publisher:
Macmillan Publishers Ltd. Publisher's website
Journal:
European Journal of Human Genetics Journal website
Volume:
17
Issue:
8
Pages:
1080-1085
Publication date:
2009-08-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:2deef271-4eee-4d89-9420-0d726f03573b
Local pid:
ora:4333

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