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Interleukin 1 (IL-1) and tumour necrosis factor synergise in the induction of IL-1 synthesis by human vascular endothelial cells.

Abstract:

We have demonstrated that recombinant interleukin 1 (IL-1) induces IL-1 alpha and IL-1 beta production by human vascular endothelial cells (EC) in vitro. The effect of IL-1 on EC was dose-dependent and not due to contamination by endotoxin or secondary to the production of tumour necrosis factor (TNF). Thymocyte co-mitogenesis was shown to be due to IL-1 by treating EC supernatants with neutralising antibodies specific for IL-1 alpha and IL-1 beta. Recombinant TNF alpha synergised with IL-1 i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Immunology letters
Volume:
19
Issue:
2
Pages:
169-173
Publication date:
1988-10-05
DOI:
EISSN:
1879-0542
ISSN:
0165-2478
URN:
uuid:2da6e3b5-87b7-47e4-9b10-748ee756cfb9
Source identifiers:
481780
Local pid:
pubs:481780

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