Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action.

Journal article

Due to their ability to mimic the actions of mammalian estrogens, soy phytoestrogens have been proposed as potential therapeutic agents to aid in preventing postmenopausal bone loss. In vitro, phytoestrogens promote osteoblastogenesis and inhibit osteoclastogenesis. Although a relatively large number of intervention studies have been undertaken in animals and humans, the efficacy of phytoestrogens as bone-protective agents in vivo remains unclear. Differences in the bioactivities of individua...

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Authors: Poulsen, R; Kruger, M

• Publication status: Published
• Journal: Nutrition reviews
• Volume: 66
• Issue: 7
• Pages: 359-374
• Publication date: 2008-07-01
• DOI: 10.1111/j.1753-4887.2008.00046.x
• EISSN: 1753-4887
• ISSN: 0029-6643
• Language: English
• Keywords: Phytoestrogens; Disease Models, Animal; Bone Density Conservation Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Female; Soybeans; Bone and Bones; Middle Aged; Animals; Osteoporosis, Postmenopausal