Journal article
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
- Abstract:
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Background: Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of nucleoside analogues by virus-encoded thymidine (dThd) kinases (TK) represents one of the most successful strategies for antiviral chemotherapy as demonstrated for anti-herpes drugs. Vaccinia virus TK is a close orthologue of variola TK but also shares a relatively high sequence identity to human type 2 TK (hT...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1186/1472-6807-6-22
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Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- BMC Structural Biology More from this journal
- Volume:
- 6
- Article number:
- 22
- Publication date:
- 2006-01-01
- DOI:
- ISSN:
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1472-6807
Item Description
- Language:
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English
- Keywords:
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- UUID:
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uuid:2d8b11cf-bfa8-47aa-aa61-17c44b8cdd66
- Local pid:
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ora:2299
- Deposit date:
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2008-09-04
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- Copyright holder:
- El Omari et al
- Copyright date:
- 2006
- Notes:
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Citation: El Omari, K. et al. (2006). 'Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design', BMC Structural Biology, 6:22. [Available at http://www.biomedcentral.com/1472-6807/6/22]
Copyright 2006 El Omari et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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