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Journal article

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.

Abstract:

Germ-line mutations inactivating BRCA2 predispose to cancer. BRCA2-deficient cells exhibit alterations in chromosome number (aneuploidy), as well as structurally aberrant chromosomes. Here, we show that BRCA2 deficiency impairs the completion of cell division by cytokinesis. BRCA2 inactivation in murine embryo fibroblasts (MEFs) and HeLa cells by targeted gene disruption or RNA interference delays and prevents cell cleavage. Impeded cell separation is accompanied by abnormalities in myosin II...

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Publication status:
Published

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Publisher copy:
10.1126/science.1102574

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Venkitaraman, AR More by this author
Journal:
Science (New York, N.Y.)
Volume:
306
Issue:
5697
Pages:
876-879
Publication date:
2004-10-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:2d52e180-2f2b-4142-b14b-a85a5a8f1f15
Source identifiers:
110930
Local pid:
pubs:110930

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