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Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.

Abstract:

Distinct IFN-gamma and IL-2 profiles of Ag-specific CD4(+) T cells have recently been associated with different clinical disease states and Ag loads in viral infections. We assessed the kinetics and functional profile of Mycobacterium tuberculosis Ag-specific T cells secreting IFN-gamma and IL-2 in 23 patients with untreated active tuberculosis when bacterial and Ag loads are high and after curative treatment, when Ag load is reduced. The frequencies of M. tuberculosis Ag-specific IFN-gamma-s...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.178.8.5217

Authors


Millington, KA More by this author
Hackforth, S More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
178
Issue:
8
Pages:
5217-5226
Publication date:
2007-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:2d5094e7-39f8-4d8c-aee8-a0248e9d5d04
Source identifiers:
24133
Local pid:
pubs:24133

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