- Abstract:
-
Opioid painkillers are a promising treatment for chronic breathlessness, but are associated with potentially fatal side effects. In the treatment of breathlessness, their mechanisms of action are unclear. A better understanding might help to identify safer alternatives. Learned associations between previously neutral stimuli (e.g. stairs) and repeated breathlessness induce an anticipatory threat response that may worsen breathlessness, contributing to the downward spiral of decline seen in cl...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.1MB)
-
- Publisher copy:
- 10.1016/j.neuroimage.2017.01.005
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- NeuroImage Journal website
- Volume:
- 150
- Issue:
- 15 April 2017
- Pages:
- 383–394
- Publication date:
- 2017-01-03
- Acceptance date:
- 2017-01-02
- DOI:
- EISSN:
-
1095-9572
- ISSN:
-
1053-8119
- Pubs id:
-
pubs:670791
- URN:
-
uri:2d1c55c4-9ca4-42c5-835e-203ab225da14
- UUID:
-
uuid:2d1c55c4-9ca4-42c5-835e-203ab225da14
- Local pid:
- pubs:670791
- Paper number:
- 15 April 2017
- Language:
- English
- Keywords:
- Copyright holder:
- Hayen et al.
- Copyright date:
- 2017
- Notes:
- © 2017 The Author(s). Published by Elsevier Inc. Open Access funded by Medical Research Council; available under a Creative Commons license.
Journal article
Opioid suppression of conditioned anticipatory brain responses to breathlessness.
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National Institute for Health Research
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