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Journal article

Opioid suppression of conditioned anticipatory brain responses to breathlessness.

Abstract:

Opioid painkillers are a promising treatment for chronic breathlessness, but are associated with potentially fatal side effects. In the treatment of breathlessness, their mechanisms of action are unclear. A better understanding might help to identify safer alternatives. Learned associations between previously neutral stimuli (e.g. stairs) and repeated breathlessness induce an anticipatory threat response that may worsen breathlessness, contributing to the downward spiral of decline seen in cl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuroimage.2017.01.005

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
NeuroImage Journal website
Volume:
150
Issue:
15 April 2017
Pages:
383–394
Publication date:
2017-01-03
Acceptance date:
2017-01-02
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
Pubs id:
pubs:670791
URN:
uri:2d1c55c4-9ca4-42c5-835e-203ab225da14
UUID:
uuid:2d1c55c4-9ca4-42c5-835e-203ab225da14
Local pid:
pubs:670791
Paper number:
15 April 2017

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