The lymphatic filariasis treatment study landscape: A systematic review of study characteristics and the case for an individual participant data platform

Journal article

Lymphatic filariasis (LF) and onchocerciasis (ONC) are neglected tropical diseases caused by vector-borne parasitic nematodes. Mass drug administration (MDA) is the primary control strategy employed in endemic areas, disrupting transmission by targeting the microfilarial stage of the parasitic life cycle. The lack of an adulticidal agent in MDA makes eliminating these diseases very difficult. The anthelmintic Emodepside (Emo), a selective activator of SLO-1 potassium channels, exhibits both microfilaricidal and macrofilaricidal properties and is considered a promising candidate for MDA inclusion. However, Emo shows reduced efficacy against Brugia malayi, one of the causative agents of LF. Here, we investigate the effects of Emo and the mammalian BK channel activator, NS11021, separately and in combination on Xenopus oocytes expressing Brugia malayi SLO-1F channels. Using two-electrode voltage clamp electrophysiology, we show that NS11021 is a positive allosteric modulator of Brugia malayi SLO-1F channels and potentiates the effect of Emo

Authors: Freitas, LT; Khan, MA; Uddin, A; Halder, JB; Singh-Phulgenda, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS Neglected Tropical Diseases
• Volume: 18
• Issue: 1
• Pages: e0011882-e0011882
• Publication date: 2024-01-16
• DOI: 10.1371/journal.pntd.0011882
• EISSN: 1935-2735
• ISSN: 1935-2727
• Language: English
• Keywords: Filariasis; Neglected tropical diseases; Veterinary medicine; Helminths; Mass drug administration; Population; Public health; Medicine; Biology; Psychiatry; Surgery; Immunology; Albendazole; Intervention (counseling); MEDLINE; Internal medicine; Environmental health; Lymphatic filariasis; Systematic review; Family medicine; Ivermectin; Disease; Diethylcarbamazine; Pathology; Tropical disease