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ST2 and IL-33 in pregnancy and pre-eclampsia.

Abstract:

Normal pregnancy is associated with a mild systemic inflammatory response and an immune bias towards type 2 cytokine production, whereas pre-eclampsia is characterized by a more intense inflammatory response, associated with endothelial dysfunction and a type 1 cytokine dominance. Interleukin (IL)-33 is a newly described member of the IL-1 family, which binds its receptor ST2L to induce type 2 cytokines. A soluble variant of ST2 (sST2) acts as a decoy receptor to regulate the activity of IL-3...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
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Journal:
PloS one
Volume:
6
Issue:
9
Pages:
e24463
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:2d001e08-03bf-48fe-acdf-c572a9fb3931
Source identifiers:
248275
Local pid:
pubs:248275

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