MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

Webb, JD; Murányi, A; Pugh, CW; Ratcliffe, PJ; Coleman, ML

Abstract:

The asparaginyl hydroxylase FIH [factor inhibiting HIF (hypoxia-inducible factor)] was first identified as a protein that inhibits transcriptional activation by HIF, through hydroxylation of an asparagine residue in the CAD (C-terminal activation domain). More recently, several ARD [AR (ankyrin repeat) domain]-containing proteins were identified as FIH substrates using FIH interaction assays. Although the function(s) of these ARD hydroxylations is unclear, expression of the ARD protein Notch1...

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APA Style

Webb, J. D., Murányi, A., Pugh, C. W., Ratcliffe, P. J., & Coleman, M. L. (2009). MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). The Biochemical Journal, 420(2), 327–333.

MLA Style

Webb, J. D., et al. “MYPT1, The Targeting Subunit of Smooth-Muscle Myosin Phosphatase, Is a Substrate for the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor (FIH).” The Biochemical Journal, vol. 420, no. 2, 2009, pp. 327–33.

Chicago Style

Webb, JD, A Murányi, CW Pugh, PJ Ratcliffe, and ML Coleman. 2009. “MYPT1, The Targeting Subunit of Smooth-Muscle Myosin Phosphatase, Is a Substrate for the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor (FIH).” The Biochemical Journal 420 (2): 327–33.
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