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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

Abstract:

The asparaginyl hydroxylase FIH [factor inhibiting HIF (hypoxia-inducible factor)] was first identified as a protein that inhibits transcriptional activation by HIF, through hydroxylation of an asparagine residue in the CAD (C-terminal activation domain). More recently, several ARD [AR (ankyrin repeat) domain]-containing proteins were identified as FIH substrates using FIH interaction assays. Although the function(s) of these ARD hydroxylations is unclear, expression of the ARD protein Notch1...

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Publication status:
Published

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Publisher copy:
10.1042/bj20081905

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
The Biochemical journal
Volume:
420
Issue:
2
Pages:
327-333
Publication date:
2009-06-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:2cd27d9c-6ebd-40eb-bd91-f911e5eb35ed
Source identifiers:
34627
Local pid:
pubs:34627

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