Expression of TRAIL and TRAIL receptors in normal and malignant tissues.

Journal article

TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, is a member of the TNF family of proteins. Tumour cells were initially found to have increased sensitivity to TRAIL compared with normal cells, raising hopes that TRAIL would prove useful as an anti-tumor agent. The production of reliable monoclonal antibodies against TRAIL and its receptors that can stain fixed specimens will allow a thorough analysis of their expression on normal and malignant tissues. Here we report the genera...

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Authors: Daniels, R; Turley, H; Kimberley, F; Liu, X; Mongkolsapaya, J

• Publication status: Published
• Journal: Cell research
• Volume: 15
• Issue: 6
• Pages: 430-438
• Publication date: 2005-06-01
• DOI: 10.1038/sj.cr.7290311
• EISSN: 1748-7838
• ISSN: 1001-0602
• Language: English
• Keywords: Tissue Distribution; Neoplasms; Antibodies, Monoclonal; Humans; TNF-Related Apoptosis-Inducing Ligand; Receptors, TNF-Related Apoptosis-Inducing Ligand; Apoptosis; Receptors, Tumor Necrosis Factor; Male; Staining and Labeling; Jurkat Cells; Female; Tumor Necrosis Factor-alpha; Immunohistochemistry; GPI-Linked Proteins; Membrane Glycoproteins; Tumor Necrosis Factor Decoy Receptors; Apoptosis Regulatory Proteins