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Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.

Abstract:
Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
van Vugt, M More by this author
Teja-Isavadharm, P More by this author
Siriyanonda, D More by this author
Rasameesoroj, M More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
46
Issue:
4
Pages:
1125-1127
Publication date:
2002-04-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:2cbc44e2-5e90-4d9c-ac28-9b8618ed772d
Source identifiers:
17962
Local pid:
pubs:17962

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