Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.

Journal article

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

Authors: Newton, P; van Vugt, M; Teja-Isavadharm, P; Siriyanonda, D; Rasameesoroj, M

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 46
• Issue: 4
• Pages: 1125-1127
• Publication date: 2002-04-01
• DOI: 10.1128/aac.46.4.1125-1127.2002
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Adult; Antimalarials; Male; Area Under Curve; Spectrophotometry, Ultraviolet; Artemisinins; Malaria, Falciparum; Aged; Double-Blind Method; Chromatography, High Pressure Liquid; Cross-Over Studies; Sesquiterpenes; Half-Life; Adolescent; Acute Disease; Biological Availability; Vietnam; Humans; Middle Aged; Female