Journal article
The immunology of Zika virus
- Abstract:
- Zika virus (ZIKV) was initially thought to cause only mild, self-limiting symptoms. However, recent outbreaks have been associated with the autoimmune disease Guillain-Barré syndrome and causally linked to a congenital malformation known as microcephaly. This has led to an urgent need for a safe and effective vaccine. A comprehensive understanding of the immunology of ZIKV infection is required to aid in the design of such a vaccine. Whilst details of both innate and adaptive immune responses to ZIKV are emerging, further research is needed. As immunopathogenesis has been implicated in poor outcomes following infection with the related dengue virus, identification of cross-reactive immune responses between flaviviruses and the impact they may have on disease progression is also of high importance.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 892.4KB, Terms of use)
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- Publisher copy:
- 10.12688/f1000research.12271.1
Authors
- Publisher:
- F1000Research
- Journal:
- F1000Research More from this journal
- Volume:
- 7
- Article number:
- 203
- Publication date:
- 2018-02-19
- Acceptance date:
- 2018-02-14
- DOI:
- ISSN:
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2046-1402
- Pmid:
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29527300
- Language:
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English
- Keywords:
- Pubs id:
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pubs:829422
- UUID:
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uuid:2caeaeca-21db-4a83-8445-c301cdab1d3c
- Local pid:
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pubs:829422
- Source identifiers:
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829422
- Deposit date:
-
2018-07-24
Terms of use
- Copyright holder:
- Culshaw et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Culshaw et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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